Article
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2009
Zheng Wei, Xin Na, Chi Zhi-Hong, Zhao Bo-Lu, Zhang Jie, Li Jia-Yi, Wang Zhan-You
Abstract excerpt
The amyloid-beta precursor protein (APP) and its pathogenic byproduct beta-amyloid peptide (Abeta) play central roles in the pathogenesis of Alzheimer's disease (AD). Reduction in levels of the potentially toxic Abeta is one of the most important therapeutic goals in AD. Recent studies have shown that bivalent metals such as iron, copper, and zinc are involved in APP expression, Abeta deposition, and senile...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.