Article
Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma.
Genes, chromosomes & cancer - 1 Mar 2016
Mareschal Sylvain, Dubois Sydney, Viailly Pierre-Julien, Bertrand Philippe, Bohers Elodie, Maingonnat Catherine, Jaïs Jean-Philippe, Tesson Bruno, Ruminy Philippe, Peyrouze Pauline, Copie-Bergman Christiane, Fest Thierry, Jo Molina Thierry, Haioun Corinne, Salles Gilles, Tilly Hervé, Lecroq Thierry, Leroy Karen, Jardin Fabrice
Abstract excerpt
Despite the many efforts already spent to enumerate somatic mutations in diffuse large B-cell lymphoma (DLBCL), previous whole-genome and whole-exome studies conducted on patients of mixed outcomes failed at characterizing the 30% of patients who will relapse or resist current immunochemotherapies. To address this issue, we performed whole-exome sequencing of normal/tumoral DNA pairs in 14 relapsed/refractory...
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