Article
A role for the TIM-3/GAL-9/BAT3 pathway in determining the clinical phenotype of multiple sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2014
Saresella Marina, Piancone Federica, Marventano Ivana, La Rosa Francesca, Tortorella Paola, Caputo Domenico, Rovaris Marco, Clerici Mario
Abstract excerpt
T-cell immunoglobulin and mucin domain 3 (Tim-3) ligates galectin-9 (Gal-9); this process, resulting in the inhibition of Th1 responses and in the apoptosis of antigen-specific cells, is hampered by binding of the molecular adaptor human leukocyte antigen B (HLA-B)-associated transcript 3 (Bat3) to the intracellular tail of Tim-3. Apoptosis of myelin basic protein (MBP)-specific T lymphocytes correlates with...
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