Article
A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jan 2013
Rossi Silvia, Motta Caterina, Studer Valeria, Monteleone Fabrizia, De Chiara Valentina, Buttari Fabio, Barbieri Francesca, Bernardi Giorgio, Battistini Luca, Cutter Gary, Stüve Olaf, Salvetti Marco, Centonze Diego
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) patients discontinuing natalizumab treatment are at risk of disease reactivation. No clinical or surrogate parameters exist to identify patients at risk of post-natalizumab MS reactivation. OBJECTIVE: To determine the role of natalizumab-induced lymphocytosis and of Akt polymorphisms in disease reactivation after natalizumab discontinuation. METHODS: Peripheral leukocyte count...
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