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Article

CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis.

Cell death & disease - 29 Oct 2021

Feizi Neda, Focaccetti Chiara, Pacella Ilenia, Tucci Gloria, Rossi Alessandra, Costanza Massimo, Pedotti Rosetta, Sidney John, Sette Alessandro, La Rocca Claudia, Procaccini Claudio, Matarese Giuseppe, Barnaba Vincenzo, Piconese Silvia

Abstract excerpt

The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8+ T cells. We have previously shown that, in MS, activated T cells undergoing apoptosis induce a CD8+ T cell response directed against antigens that are unveiled during the apoptotic process, namely caspase-cleaved structural proteins such as non-muscle myosin and vimentin. Here, we have...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Epitopes, T-Lymphocyte

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Source

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Identifiers

PMID: 34716313
DOI: 10.1038/s41419-021-04310-6
PMCID: PMC8556378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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