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Article

Ancestry and other genetic associations with plasma PCSK9 response to simvastatin.

Pharmacogenetics and genomics - 1 Oct 2014

Theusch Elizabeth, Medina Marisa W, Rotter Jerome I, Krauss Ronald M

Abstract excerpt

OBJECTIVE: Statins stimulate transcription of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of the low-density lipoprotein receptor, thus blunting the cholesterol-lowering effects of statin treatment. Although there is interindividual variation in PCSK9 statin response, little is known about ancestral and other genetic factors that could contribute to this variation. METHODS: We...

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Identifiers

PMID: 25089948
DOI: 10.1097/FPC.0000000000000081
PMCID: PMC4159722

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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