Article
The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity.
Biochemical and biophysical research communications - 23 Sept 2005
Voisin Stéphanie, Ouimet Tanja
Abstract excerpt
Modeling the three-dimensional structure of neprilysin 2 (NEP2) using the crystal structure of neprilysin as template revealed that their active sites share many common features, though slight differences therein cannot completely account for their specific pharmacological profiles. Recent evidence also suggest that residues outside the active site can play crucial functions in the maturation and enzymatic...
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