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Article

Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid Peptide in the Brain

1 Dec 2000

Abstract excerpt

Amyloid beta peptide (Abeta) is a physiological peptide that is constantly catabolized in the brain. We previously demonstrated that an endopeptidase sensitive to phosphoramidon and thiorphan conducts the initial rate-limiting proteolysis of Abeta in vivo, but the exact molecular identity of the peptidase(s) has remained unknown because of the molecular redundancy of such activity. We analyzed the brain-derived...

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PMID: 11098130
DOI: 10.1093/oxfordjournals.jbchem.a022839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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