Article
Hepatocellular carcinoma: novel molecular targets in carcinogenesis for future therapies.
BioMed research international - 1 Jan 2014
Bertino Gaetano, Demma Shirin, Ardiri Annalisa, Proiti Maria, Gruttadauria Salvatore, Toro Adriana, Malaguarnera Giulia, Bertino Nicoletta, Malaguarnera Michele, Malaguarnera Mariano, Di Carlo Isidoro
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma is one of the most common and lethal malignant tumors worldwide. Over the past 15 years, the incidence of HCC has more than doubled. Due to late diagnosis and/or advanced underlying liver cirrhosis, only limited treatment options with marginal clinical benefit are available in up to 70% of patients. During the last decades, no effective conventional cytotoxic systemic therapy...
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