Molecular pathogenesis of hepatocellular carcinoma.

doi:10.1111/j.1478-3231.2007.01637.x

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Article

Molecular pathogenesis of hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2008

Wong Chun-Ming, Ng Irene O L

Abstract excerpt

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Hepatocarcinogenesis is a multistep process evolving from normal through chronic hepatitis/cirrhosis and dysplastic nodules to HCC. With advances in molecular methods, there is a growing understanding of the molecular mechanisms in hepatocarcinogenesis. Hepatocarcinogenesis is strongly linked to...

Topics

Carcinoma, Hepatocellular
Chromosomal Instability
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans
Loss of Heterozygosity
Mutation
Signal Transduction
Wnt Proteins
beta Catenin
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 18069974
DOI: 10.1111/j.1478-3231.2007.01637.x

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