Article
Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.
American journal of human genetics - 7 Aug 2014
Hause Ronald J, Stark Amy L, Antao Nirav N, Gorsic Lidija K, Chung Sophie H, Brown Christopher D, Wong Shan S, Gill Daniel F, Myers Jamie L, To Lida Anita, White Kevin P, Dolan M Eileen, Jones Richard Baker
Abstract excerpt
Many genetic variants associated with human disease have been found to be associated with alterations in mRNA expression. Although it is commonly assumed that mRNA expression changes will lead to consequent changes in protein levels, methodological challenges have limited our ability to test the degree to which this assumption holds true. Here, we further developed the micro-western array approach and globally...
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