Article
Progressive restriction in fate potential by neural progenitors during cerebral cortical development.
Development (Cambridge, England) - 1 Jul 2000
Desai A R, McConnell S K
Abstract excerpt
During early stages of cerebral cortical development, progenitor cells in the ventricular zone are multipotent, producing neurons of many layers over successive cell divisions. The laminar fate of their progeny depends on environmental cues to which the cells respond prior to mitosis. By the end of neurogenesis, however, progenitors are lineally committed to producing upper-layer neurons. Here we assess the...
Topics
- Animals
- Cell Lineage
- Cell Movement
- Cell Transplantation
- Cerebral Cortex
- Ferrets
- Models, Biological
- Nervous System
- Neurons
- Perfusion
- Phenotype
- Stem Cells