Article
Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.
The Clinical journal of pain - 1 Jan 2015
Orrey Danielle C, Halawa Omar I, Bortsov Andrey V, Shupp Jeffrey W, Jones Samuel W, Haith Linwood R, Hoskins Janelle M, Jordan Marion H, Bangdiwala Shrikant I, Roane Brandon R, Platts-Mills Timothy F, Holmes James H, Hwang James, Cairns Bruce A, McLean Samuel A
Abstract excerpt
BACKGROUND: Results of previous studies suggest that β-adrenoreceptor activation may augment pain, and that β-adrenoreceptor antagonists may be effective in reducing pain, particularly in individuals not homozygous for the catechol-O-methyltransferase (COMT) high-activity haplotype. MATERIALS AND METHODS: Consenting patients admitted for thermal burn injury at participating burn centers were genotyped; those who...
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