Article
Race and Melanocortin 1 Receptor Polymorphism R163Q Are Associated with Post-Burn Hypertrophic Scarring: A Prospective Cohort Study.
The Journal of investigative dermatology - 1 Oct 2015
Sood Ravi F, Hocking Anne M, Muffley Lara A, Ga Maricar, Honari Shari, Reiner Alexander P, Rowhani-Rahbar Ali, Gibran Nicole S
Abstract excerpt
The genetic determinants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to fibrogenesis in experimental models. To examine the associations between self-identified race and MC1R single-nucleotide polymorphisms (SNPs) with severity of post-burn HTS, we conducted a prospective cohort study of burned adults admitted to our institution over 7 years....
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