Article
Tumor necrosis factor-alpha and polycystic ovarian syndrome: a clinical, biochemical, and molecular genetic study.
Genetic testing and molecular biomarkers - 1 Sept 2014
Thathapudi Sujatha, Kodati Vijayalakshmi, Erukkambattu Jayashankar, Katragadda Anuradha, Addepally Uma, Hasan Qurratulain
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) appears to be linked with hyperandrogenism (HA), increased insulin resistance (IR), and obesity (Ob), which were common features noted with polycystic ovarian syndrome (PCOS). Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS, as well as a C850T (rs1799724) polymorphism in the promoter region of the TNF-α gene, in a group of 204 PCOS...
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