Article
Preliminary study showing no association between G238A (rs361525) tumor necrosis factor-α (TNF-α) gene polymorphism and its serum level, hormonal and biochemical aspects of polycystic ovary syndrome.
BMC medical genetics - 22 Aug 2018
Kordestani Fahimeh, Mazloomi Sahar, Mortazavi Yousef, Mazloomzadeh Saeideh, Fathi Mojtaba, Rahmanpour Haleh, Nazarian Abolfazl
Abstract excerpt
BACKGROUND: Polycystic ovary syndrome (PCOS) is the main cause of female infertility. Interactions among genetic, biochemical, and immunological factors can affect the pathogenesis of PCOS. As a proinflammatory cytokine, tumor necrosis factor-α (TNF-α) plays an important role in this regard. The present study aimed to evaluate the association of the rs361525 gene single-nucleotide polymorphism (SNP) and TNF-α...
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