Article

A simple adeno-associated virus-based approach for the generation of cardiac genetic models in rats

2020-12-10

Abstract excerpt

<h4>Background: </h4> Heart failure is a major health problem and progress in this field relies on better understanding of the mechanisms and development of novel therapeutics using animal models. The rat may be preferable to the mouse as a cardiovascular disease model due to its closer physiology to humans and due to its large size that facilitates surgical and monitoring procedures. However, unlike the mouse, ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81bb626a-ddd3-521e-8a5c-f3373f115421
DOI: 10.12688/f1000research.27675.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A simple adeno-associated virus-based approach for the generation of cardiac genetic models in ratsDOI 10.12688/f1000research.27675.1Read

Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart FailureSemantic proximity Read

AAV Vectors for Cardiac Gene Transfer: Experimental Tools and Clinical OpportunitiesSemantic proximity Read

Cardiac gene therapy with adeno-associated virus-based vectorsSemantic proximity Read

Adeno-associated virus-mediated gene therapy in cardiovascular diseaseSemantic proximity Read

Adeno-associated virus mediated gene delivery: Implications for scalable <i>in vitro</i> and <i>in vivo</i> cardiac optogenetic modelsSemantic proximity Read

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and RatSemantic proximity Read

Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular SystemSemantic proximity Read

Lost in TransgenesisSemantic proximity Read

2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.Semantic proximity Read

With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failureSemantic proximity Read

Transgenic rabbit models for cardiac disease researchSemantic proximity Read

Principles of genetic murine models for cardiac disease.Semantic proximity Read