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Article

Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.

Journal of leukocyte biology - 1 Nov 2014

Tang Lunxian, Bai Jianwen, Chung Chun-Shiang, Lomas-Neira Joanne, Chen Yaping, Huang Xin, Ayala Alfred

Abstract excerpt

The immunomodulatory effects of PD-1 and CD4(+)CD25(+) Tregs in the resolution of ALI are still poorly understood. Accordingly, 1 million Tregs were isolated from spleens of WT C57BL/6 or PD-1(-/-) mice (magnetical bead purification and subsequent labeling with/without Vybrant dye) and then AT into mice subjected to Hem shock during their resuscitation period, which were subsequently subjected to CLP/septic...

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Source

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Identifiers

PMID: 25082151
DOI: 10.1189/jlb.4MA1213-647RR
PMCID: PMC4197571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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