A 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.

doi:10.1093/annonc/mdu367

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Article

A 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2014

Chung C H, Lee J W, Slebos R J, Howard J D, Perez J, Kang H, Fertig E J, Considine M, Gilbert J, Murphy B A, Nallur S, Paranjape T, Jordan R C, Garcia J, Burtness B, Forastiere A A, Weidhaas J B

Abstract excerpt

BACKGROUND: A germline mutation in the 3'-untranslated region of KRAS (rs61764370, KRAS-variant: TG/GG) has previously been associated with altered patient outcome and drug resistance/sensitivity in various cancers. We examined the prognostic and predictive significance of this variant in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: We conducted a retrospective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Monoclonal, Humanized

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Identifiers

PMID: 25081901
DOI: 10.1093/annonc/mdu367
PMCID: PMC4207729

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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