A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis.

doi:10.1016/S1470-2045(11)70044-4

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Article

A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis.

The Lancet. Oncology - 1 Apr 2011

Paranjape Trupti, Heneghan Helen, Lindner Robert, Keane Florence K, Hoffman Aaron, Hollestelle Antoinette, Dorairaj Jemima, Geyda Kimberly, Pelletier Cory, Nallur Sunitha, Martens John Wm, Hooning Maartje J, Kerin Michael, Zelterman Daniel, Zhu Yong, Tuck David, Harris Lyndsay, Miller Nicola, Slack Frank, Weidhaas Joanne

Abstract excerpt

BACKGROUND: We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. We aimed to investigate the association of this KRAS variant with breast cancer and tumour biology. METHODS: We assessed frequency distributions of the KRAS variant in 415 patients with histologically confirmed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to 3' Untranslated Regions

Share to Genes, BRCA1

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

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Share to Receptor, ErbB-2

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Identifiers

PMID: 21435948
DOI: 10.1016/S1470-2045(11)70044-4
PMCID: PMC3488438

Genes

KRAS
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis.PMID 21435948Read ↗

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