Article
A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
PLoS genetics - 1 Jul 2014
Traylor Matthew, Mäkelä Kari-Matti, Kilarski Laura L, Holliday Elizabeth G, Devan William J, Nalls Mike A, Wiggins Kerri L, Zhao Wei, Cheng Yu-Ching, Achterberg Sefanja, Malik Rainer, Sudlow Cathie, Bevan Steve, Raitoharju Emma, Oksala Niku, Thijs Vincent, Lemmens Robin, Lindgren Arne, Slowik Agnieszka, Maguire Jane M, Walters Matthew, Algra Ale, Sharma Pankaj, Attia John R, Boncoraglio Giorgio B, Rothwell Peter M, de Bakker Paul I W, Bis Joshua C, Saleheen Danish, Kittner Steven J, Mitchell Braxton D, Rosand Jonathan, Meschia James F, Levi Christopher, Dichgans Martin, Lehtimäki Terho, Lewis Cathryn M, Markus Hugh S
Abstract excerpt
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect associations. As prevalence rates in IS are markedly affected by age, and younger onset cases may have higher genetic...
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