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Article

Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.

Genetic epidemiology - 1 Jul 2013

Traylor Matthew, Bevan Steve, Rothwell Peter M, Sudlow Cathie, Dichgans Martin, Markus Hugh S, Lewis Cathryn M

Abstract excerpt

Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. Sophisticated strategies that account for phenotypic heterogeneity may be required to uncover these genetic contributions. Age at...

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PMID: 23674248
DOI: 10.1002/gepi.21729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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