Article
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
Nature genetics - 1 Oct 2012
Holliday Elizabeth G, Maguire Jane M, Evans Tiffany-Jane, Koblar Simon A, Jannes Jim, Sturm Jonathan W, Hankey Graeme J, Baker Ross, Golledge Jonathan, Parsons Mark W, Malik Rainer, McEvoy Mark, Biros Erik, Lewis Martin D, Lincz Lisa F, Peel Roseanne, Oldmeadow Christopher, Smith Wayne, Moscato Pablo, Barlera Simona, Bevan Steve, Bis Joshua C, Boerwinkle Eric, Boncoraglio Giorgio B, Brott Thomas G, Brown Robert D, Cheng Yu-Ching, Cole John W, Cotlarciuc Ioana, Devan William J, Fornage Myriam, Furie Karen L, Grétarsdóttir Sólveig, Gschwendtner Andreas, Ikram M Arfan, Longstreth W T, Meschia James F, Mitchell Braxton D, Mosley Thomas H, Nalls Michael A, Parati Eugenio A, Psaty Bruce M, Sharma Pankaj, Stefansson Kari, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Traylor Matthew, Verhaaren Benjamin F J, Wiggins Kerri L, Worrall Bradford B, Sudlow Cathie, Rothwell Peter M, Farrall Martin, Dichgans Martin, Rosand Jonathan, Markus Hugh S, Scott Rodney J, Levi Christopher, Attia John
Abstract excerpt
Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a...
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