Article
Genetic variation at 16q24.2 is associated with small vessel stroke.
Annals of neurology - 1 Mar 2017
Traylor Matthew, Malik Rainer, Nalls Mike A, Cotlarciuc Ioana, Radmanesh Farid, Thorleifsson Gudmar, Hanscombe Ken B, Langefeld Carl, Saleheen Danish, Rost Natalia S, Yet Idil, Spector Tim D, Bell Jordana T, Hannon Eilis, Mill Jonathan, Chauhan Ganesh, Debette Stephanie, Bis Joshua C, Longstreth W T, Ikram M Arfan, Launer Lenore J, Seshadri Sudha, Hamilton-Bruce Monica Anne, Jimenez-Conde Jordi, Cole John W, Schmidt Reinhold, Słowik Agnieszka, Lemmens Robin, Lindgren Arne, Melander Olle, Grewal Raji P, Sacco Ralph L, Rundek Tatjana, Rexrode Kathryn, Arnett Donna K, Johnson Julie A, Benavente Oscar R, Wasssertheil-Smoller Sylvia, Lee Jin-Moo, Pulit Sara L, Wong Quenna, Rich Stephen S, de Bakker Paul I W, McArdle Patrick F, Woo Daniel, Anderson Christopher D, Xu Huichun, Heitsch Laura, Fornage Myriam, Jern Christina, Stefansson Kari, Thorsteinsdottir Unnur, Gretarsdottir Solveig, Lewis Cathryn M, Sharma Pankaj, Sudlow Cathie L M, Rothwell Peter M, Boncoraglio Giorgio B, Thijs Vincent, Levi Chris, Meschia James F, Rosand Jonathan, Kittner Steven J, Mitchell Braxton D, Dichgans Martin, Worrall Bradford B, Markus Hugh S
Abstract excerpt
OBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits...
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