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Article

Phase variation of poly-N-acetylglucosamine expression in Staphylococcus aureus.

PLoS pathogens - 1 Jul 2014

Brooks Jamie L, Jefferson Kimberly K

Abstract excerpt

Polysaccharide intercellular adhesin (PIA), also known as poly-N-acetyl-β-(1-6)-glucosamine (PIA/PNAG) is an important component of Staphylococcus aureus biofilms and also contributes to resistance to phagocytosis. The proteins IcaA, IcaD, IcaB, and IcaC are encoded within the intercellular adhesin (ica) operon and synthesize PIA/PNAG. We discovered a mechanism of phase variation in PIA/PNAG expression that...

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Identifiers

PMID: 25077798
DOI: 10.1371/journal.ppat.1004292
PMCID: PMC4117637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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