Article
Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis.
Journal of bacteriology - 1 Dec 2008
Sadykov Marat R, Olson Michael E, Halouska Steven, Zhu Yefei, Fey Paul D, Powers Robert, Somerville Greg A
Abstract excerpt
Staphylococcus epidermidis is a major nosocomial pathogen primarily infecting immunocompromised individuals or those with implanted biomaterials (e.g., catheters). Biomaterial-associated infections often involve the formation of a biofilm on the surface of the medical device. In S. epidermidis, polysaccharide intercellular adhesin (PIA) is an important mediator of biofilm formation and pathogenesis. Synthesis of...
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