Article
Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus.
Molecular microbiology - 1 Dec 2015
George Shilpa E, Nguyen Tran, Geiger Tobias, Weidenmaier Christopher, Lee Jean C, Liese Jan, Wolz Christiane
Abstract excerpt
Bacteria respond to ever-changing environments through several adaptive strategies. This includes mechanisms leading to a high degree of phenotypic variability within a genetically homogeneous population. In Staphylococcus aureus, the capsular polysaccharide (CP) protects against phagocytosis, but also impedes adherence to endothelial cells and/or matrix proteins. We analysed the regulation of core biosynthesis...
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