Cumulative review and meta-analyses on the association between MTHFR rs1801133 polymorphism and breast cancer risk: a pooled analysis of 83 studies with 74,019 participants.

Abstract excerpt

BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been extensively explored, but their results are conflicting rather than conclusive. To clarify the precise effects of MTHFR polymorphisms on the risk of breast cancer, a systemic review and most comprehensive meta-analysis of all available studies relating MTHFR rs1801133 gene polymorphism...

Topics

• Alleles
• Breast Neoplasms
• Ethnicity
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Methylenetetrahydrofolate Reductase (NADPH2)
• Polymorphism, Single Nucleotide