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Article

Replacement of short segments within transmembrane domains of MC2R disrupts retention signal.

Journal of molecular endocrinology - 1 Oct 2014

Fridmanis Davids, Petrovska Ramona, Pjanova Dace, Schiöth Helgi B, Klovins Janis

Abstract excerpt

The proteolysis of the pro-opiomelanocortin precursor results in the formation of melanocortins (MCs), a group of peptides that share the conserved -H-F-R-W- sequence, which acts as a pharmacophore for five subtypes of MC receptors (MCRs). MC type 2 receptor (MC2R; also known as ACTHR) is the most specialized of all the MCRs. It is predominantly expressed in the adrenal cortex and specifically binds ACTH. Unlike...

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PMID: 25074265
DOI: 10.1530/JME-14-0169

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MRAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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