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Article

60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides.

Journal of molecular endocrinology - 1 May 2016

Dores Robert M, Liang Liang, Davis Perry, Thomas Alexa L, Petko Bogdana

Abstract excerpt

The evolution of the melanocortin receptors (MCRs) is linked to the evolution of adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and their common precursor pro-opiomelanocortin (POMC). The origin of the MCRs and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evolution of the...

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Source

Identifiers

PMID: 26792827
DOI: 10.1530/JME-15-0292

Genes

POMC
MRAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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