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Article

Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling.

Biochemistry - 9 Oct 2007

Chen Min, Aprahamian Charles J, Kesterson Robert A, Harmon Carroll M, Yang Yingkui

Abstract excerpt

The melanocortin-2 receptor (MC2R), also known as the adrenocorticotropic hormone (ACTH) receptor, plays an important role in regulating and maintaining adrenocortical function, specifically steroidogenesis. Mutations of the human MC2R (hMC2R) gene have also been identified in humans with familial glucocorticoid deficiency; however, the molecular basis responsible for hMC2R ligand binding and signaling remains...

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Identifiers

PMID: 17877367
DOI: 10.1021/bi700125e
PMCID: PMC3216636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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