Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF‐β signaling regulates fibrotic expression and activity in carpal tunnel syndrome

30 Jul 2014

Abstract excerpt

Fibrosis of the subsynovial connective tissue (SSCT) is a predominant feature of carpal tunnel syndrome (CTS). While the nature of CTS has been extensively studied, little is known about the etiology of this disease. We investigated SSCT tissue from patients with CTS and control subjects using fibrosis arrays and cell culture analysis. Twofold changes in fibrotic gene expression were found in multiple genes from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective Tissue Growth Factor Research
Share to Orthopedic Surgery and Rehabilitation
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25073432
DOI: 10.1002/jor.22694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF‐β signaling regulates fibrotic expression and activity in carpal tunnel syndromePMID 25073432Read ↗

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.Semantic proximity Read ↗

Wnt/β‐catenin signaling is hyperactivated in systemic sclerosis and induces Smad‐dependent fibrotic responses in mesenchymal cellsSemantic proximity Read ↗

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosisSemantic proximity Read ↗

C-X-C domain ligand 14-mediated stromal cell–macrophage interaction as a therapeutic target for hand dermal fibrosisSemantic proximity Read ↗

Transcriptomic evidence linking adaptive immunity and the IGF-1 pathway in carpal tunnel syndromeSemantic proximity Read ↗

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast TransitionSemantic proximity Read ↗

Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?Semantic proximity Read ↗

Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis.Semantic proximity Read ↗

Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes.Semantic proximity Read ↗

Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β ResponsesSemantic proximity Read ↗

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts.Semantic proximity Read ↗

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.