Article

Transcriptomic evidence linking adaptive immunity and the IGF-1 pathway in carpal tunnel syndrome

2025-11-19

Abstract excerpt

Carpal tunnel syndrome (CTS), the most common entrapment neuropathy, is characterised by fibrosis and thickening of the subsynovial connective tissue (SSCT) surrounding the median nerve. Although traditionally considered “non-inflammatory,” emerging evidence indicates immune involvement, including elevated cytokines and T-lymphocyte infiltration within the SSCT. Insulin-like growth factor 1 (IGF-1) has been implic...

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Literature Corpus work: 77a0b8e0-6302-57ca-ac4e-f0f1a5dccba9
DOI: 10.1101/2025.11.17.25340409

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