Article
Lack of association of the rs2476601 PTPN22 gene polymorphism with transplanted kidney function.
Annals of transplantation - 1 Jan 2000
Domański Leszek, Bobrek-Lesiakowska Katarzyna, Kłoda Karolina, Pawlik Andrzej, Safranow Krzysztof, Kurzawski Mateusz, Wiśniewska Magda, Sulikowski Tadeusz, Ciechanowski Kazimierz
Abstract excerpt
BACKGROUND: PTPN22 gene, located on the long arm of chromosome 1, encodes PTPN22 protein, known as lymphoid tyrosine phosphatase (Lyp). The function of Lyp is suggested to be negative regulation of T-cell reaction through dephosphorylation of Src family kinases--Lck and Fyn, negative regulatory kinase Csk and other signaling molecules. Several studies suggested that individuals lacking the C allele of the C1858T...
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