Article
Low Frequencies of Autoimmunity-Associated PTPN22 Polymorphisms in MODY Patients, Including Those Transiently Expressing Islet Cell Autoantibodies.
International archives of allergy and immunology - 1 Jan 2015
Heneberg Petr, Malá Milena, Yorifuji Tohru, Gat-Yablonski Galia, Lebenthal Yael, Tajima Toshihiro, Nogaroto Viviane, Rypáčková Blanka, Kocková Lucie, Urbanová Jana, Anděl Michal
Abstract excerpt
BACKGROUND: The protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene encodes lymphoid tyrosine phosphatase (LYP), which is expressed primarily in lymphoid tissues. The functional but geographically highly variable PTPN22 single-nucleotide polymorphisms (SNPs), particularly c.1858C>T, contribute to the onset and progression of autoimmunity-associated diseases and facilitate the expression of...
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