CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

doi:10.1111/j.1360-0443.2012.03922.x

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Article

CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

Addiction (Abingdon, England) - 1 Nov 2012

Rice John P, Hartz Sarah M, Agrawal Arpana, Almasy Laura, Bennett Siiri, Breslau Naomi, Bucholz Kathleen K, Doheny Kimberly F, Edenberg Howard J, Goate Alison M, Hesselbrock Victor, Howells William B, Johnson Eric O, Kramer John, Krueger Robert F, Kuperman Samuel, Laurie Cathy, Manolio Teri A, Neuman Rosalind J, Nurnberger John I, Porjesz Bernice, Pugh Elizabeth, Ramos Erin M, Saccone Nancy, Saccone Scott, Schuckit Marc, Bierut Laura J

Abstract excerpt

AIMS: Nicotine dependence is a highly heritable disorder associated with severe medical morbidity and mortality. Recent meta-analyses have found novel genetic loci associated with cigarettes per day (CPD), a proxy for nicotine dependence. The aim of this paper is to evaluate the importance of phe...

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Identifiers

PMID: 22524403
DOI: 10.1111/j.1360-0443.2012.03922.x
PMCID: PMC3427406

Genes

CPD
CHRNB3
FTCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22524403-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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