CHRNA3 and CYP3A5*3 genotype, lung function and chronic obstructive pulmonary disease in the general population.

doi:10.1097/FPC.0000000000000038

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CHRNA3 and CYP3A5*3 genotype, lung function and chronic obstructive pulmonary disease in the general population.

Pharmacogenetics and genomics - 1 Apr 2014

Kaur-Knudsen Diljit, Bojesen Stig E, Nordestgaard Børge G

Abstract excerpt

OBJECTIVE: Genetic variations are most likely an additional risk factor besides tobacco smoking per se for the risk of chronic obstructive pulmonary disease (COPD). In this study, we compared genetic variants influencing the effect of smoking on COPD, that is, the effect of the well-known splicing defect polymorphism, CYP3A5*3 (rs776746), identified before genome-wide association studies, with the genome-wide...

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PMID: 24535486
DOI: 10.1097/FPC.0000000000000038

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CHRNA3

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