Article
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.
Cancer research - 15 Nov 2008
Le Marchand Loïc, Derby Kiersten S, Murphy Sharon E, Hecht Stephen S, Hatsukami Dorothy, Carmella Steven G, Tiirikainen Maarit, Wang Hansong
Abstract excerpt
A locus at 15q24/15q25.1, which includes the nicotinic acetylcholine receptor A subunits 3 and 5 (CHRNA3 and CHRNA5) genes, has recently been associated with lung cancer risk, self-reported number of cigarettes smoked per day, and a nicotine dependence scale. It is not clear whether the association with lung cancer is direct or mediated through differences in smoking behavior. We used urinary biomarkers to test...
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