Article
Double mutation in the pfmdr1 gene is associated with emergence of chloroquine-resistant Plasmodium falciparum malaria in Eastern India.
Antimicrobial agents and chemotherapy - 1 Oct 2014
Das Sabyasachi, Mahapatra Santanu Kar, Tripathy Satyajit, Chattopadhyay Sourav, Dash Sandeep Kumar, Mandal Debasis, Das Balaram, Hati Amiya Kumar, Roy Somenath
Abstract excerpt
Malaria is a major public health problem in tropical and subtropical countries, including India. This study elucidates the cause of chloroquine treatment failure (for Plasmodium falciparum infection) before the introduction of artemisinin combination therapy. One hundred twenty-six patients were randomized to chloroquine treatment, and the therapeutic efficacy was monitored from days 1 to 28. An in vitro...
Topics
- Antimalarials
- Chloroquine
- Drug Resistance
- Humans
- India
- Malaria, Falciparum
- Multidrug Resistance-Associated Proteins
- Mutation
- Plasmodium falciparum