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Staphylococcus aureus Hyaluronidase Is a CodY-Regulated Virulence Factor

29 Jul 2014

Abstract excerpt

Staphylococcus aureus is a Gram-positive pathogen that causes a diverse range of bacterial infections. Invasive S. aureus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes to cause disease. Our studies have focused on the secreted enzyme hyaluronidase (HysA), which cleaves the hyaluronic acid polymer at the β-1,4 glycosidic bond. In the study described in this report, we have...

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PMID: 25069977
DOI: 10.1128/iai.01710-14

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