Article
Nutritional Regulation of the Sae Two-Component System by CodY in Staphylococcus aureus
29 Jan 2018
Abstract excerpt
ABSTRACT Staphylococcus aureus subverts innate defenses during infection in part by killing host immune cells to exacerbate disease. This human pathogen intercepts host cues and activates a transcriptional response via the S. aureus exoprotein expression (SaeR/SaeS [SaeR/S]) two-component system to secrete virulence factors critical for pathogenesis. We recently showed that the transcriptional repressor CodY...
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