Article
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Endocrine journal - 1 Jan 2014
Nakajima Yasuyo, Okamura Takashi, Gohko Tamae, Satoh Tetsurou, Hashimoto Koshi, Shibusawa Nobuyuki, Ozawa Atsushi, Ishii Sumiyasu, Tomaru Takuya, Horiguchi Kazuhiko, Okada Shuichi, Takata Daisuke, Rokutanda Nana, Horiguchi Jun, Tsushima Yoshito, Oyama Tetsunari, Takeyoshi Izumi, Yamada Masanobu
Abstract excerpt
Somatic mutations of the catalytic subunit of the cyclic AMP-dependent protein kinase (PRKACA) gene have recently been identified in about 35% of cortisol-producing adenomas (CPAs), with the affected patients showing overt Cushing's syndrome. Since we recently reported higher prevalence of mutations of the KCNJ5 gene and associations with autonomous cortisol secretion in Japanese aldosterone-producing adenomas...
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