Article
GNAS mutations in adrenal aldosterone-producing adenomas.
Endocrine journal - 1 Jan 2016
Nakajima Yasuyo, Okamura Takashi, Horiguchi Kazuhiko, Gohko Tamae, Miyamoto Tomoko, Satoh Tetsurou, Ozawa Atsushi, Ishii Sumiyasu, Yamada Eijiro, Hashimoto Koshi, Okada Shuichi, Takata Daisuke, Horiguchi Jun, Yamada Masanobu
Abstract excerpt
Mutations in GNAS, which encodes Gsα, have been documented in detail, particularly in human pituitary GH-secreting adenomas. Mutations have also recently been reported in adrenal cortisol-producing adenomas (CPAs), in addition to those in the PRKACA gene. However, mutations have not yet been examined in aldosterone-producing adenomas (APAs). Therefore, we herein investigated mutations in the GNAS gene in APAs....
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