Article
Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2006
Klein Alexis, Deckert Valérie, Schneider Martina, Dutrillaux Fabienne, Hammann Arlette, Athias Anne, Le Guern Naig, Pais de Barros Jean-Paul, Desrumaux Catherine, Masson David, Jiang Xian-Cheng, Lagrost Laurent
Abstract excerpt
OBJECTIVE: The aim of the present study was to assess the effect of alpha-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties. METHODS AND RESULTS: In vitro alpha-tocopherol enrichment of isolated erythrocytes significantly decreased PS externalization as assessed by lower Annexin...
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