Article
Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) - 1 Nov 1990
Ehmann W C, Dancis A, Ferziger R, Karpatkin S
Abstract excerpt
Three previous articles have reported a PLA1 antigen in the plasma of stored blood which is capable of binding to PLA1-negative platelets in the presence of divalent cations, rendering them PLA1 positive. Such a mechanism could explain the enigma of posttransfusion purpura (PTP), i.e., severe thrombocytopenia in a healthy subject with PLA1-negative platelets secondary to the infusion of blood containing...
Topics
- Antigens, Human Platelet
- Blood Platelets
- Epitopes
- Humans
- Integrin beta3
- Isoantigens
- Phenotype
- Platelet Membrane Glycoproteins
- Purpura, Thrombocytopenic
- Transfusion Reaction