Article
Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients.
Annals of hematology - 1 Apr 2018
Tong Dongxia, Yu Muxin, Guo Li, Li Tao, Li Jihe, Novakovic Valerie A, Dong Zengxiang, Tian Ye, Kou Junjie, Bi Yayan, Wang Jinghua, Zhou Jin, Shi Jialan
Abstract excerpt
The mechanisms of thrombogenicity in essential thrombocythemia (ET) are complex and not well defined. Our objective was to explore whether phosphatidylserine (PS) exposure on blood cells and endothelial cells (ECs) can account for the increased thrombosis and distinct thrombotic risks among mutational subtypes in ET. Using flow cytometry and confocal microscopy, we found that the levels of PS-exposing...
Topics
- Adult
- Aged
- Amino Acid Substitution
- Blood Platelets
- Calreticulin
- Cells, Cultured
- China
- Endothelium, Vascular
- Erythrocytes
- Female
- Human Umbilical Vein Endothelial Cells
- Humans
- Janus Kinase 2