Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

Journal of medicinal chemistry - 14 Aug 2014

Ge Xiaopeng, MacRaild Christopher A, Devine Shane M, Debono Cael O, Wang Geqing, Scammells Peter J, Scanlon Martin J, Anders Robin F, Foley Michael, Norton Raymond S

Abstract excerpt

We established an efficient means of probing ligand-induced conformational change in the malaria drug target AMA1 using 19F NMR. AMA1 was labeled with 5-fluorotryptophan (5F-Trp), and the resulting 5F-Trp resonances were assigned by mutagenesis of the native Trp residues. By introducing additional Trp residues at strategic sites within a ligand-responsive loop, we detected distinct conformational consequences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Protozoan
Share to Antimalarials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Plasmodium falciparum

Share to Protein Conformation

Share to Protozoan Proteins

Share to Recombinant Proteins

Source

Identifiers

PMID: 25068708
DOI: 10.1021/jm500390g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.PMID 25068708Read ↗

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment ScreeningSemantic proximity Read ↗

Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain RecognitionSemantic proximity Read ↗

Predicting 19 F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase-Inhibitor Complex.Semantic proximity Read ↗

Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory AntibodySemantic proximity Read ↗

Ligand modulation of the conformational dynamics of the A2A adenosine receptor revealed by single-molecule fluorescence.Semantic proximity Read ↗

Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding.Semantic proximity Read ↗

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.Semantic proximity Read ↗

(19)F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability.Semantic proximity Read ↗

Functional dynamics and allosteric modulation of TRPA1.Semantic proximity Read ↗

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.Semantic proximity Read ↗

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates.Semantic proximity Read ↗

Tracking Transitions in Spider Wrapping Silk Conformation and Dynamics by (19)F Nuclear Magnetic Resonance Spectroscopy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.