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Article

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.

Chemical biology & drug design - 1 Nov 2014

Leung Eleanor W W, Yagi Hiromasa, Harjani Jitendra R, Mulcair Mark D, Scanlon Martin J, Baell Jonathan B, Norton Raymond S

Abstract excerpt

SPRY domain-containing SOCS box protein 2 (SPSB2) regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation. Inhibiting this interaction prolongs the intracellular lifetime of iNOS, leading in turn to enhanced killing of infectious pathogens such as bacteria and parasites. SPSB2 recognizes a linear motif (DINNN) in the disordered N-terminus of iNOS, and ligands that target the...

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Identifiers

PMID: 24813479
DOI: 10.1111/cbdd.12355

Genes

SPSB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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