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Article

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates.

The Journal of biological chemistry - 26 Mar 2010

Lampe Jed N, Brandman Relly, Sivaramakrishnan Santhosh, de Montellano Paul R Ortiz

Abstract excerpt

Cytochrome P450 enzymes are versatile catalysts involved in a wide variety of biological processes from hormonal regulation and antibiotic synthesis to drug metabolism. A hallmark of their versatility is their promiscuous nature, allowing them to recognize a wide variety of chemically diverse sub...

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Identifiers

PMID: 20097757
DOI: 10.1074/jbc.M109.087593
PMCID: PMC2843209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20097757-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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