Article
COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events.
Genes - 29 Jan 2023
Tosato Sarah, Bonetto Chiara, De Santi Katia, Lasalvia Antonio, Gennarelli Massimo, Cristofalo Doriana, Bertani Mariaelena, Ruggeri Mirella, On Behalf Of The Picos-Veneto Group
Abstract excerpt
Serotonergic and dopaminergic systems are involved in the regulation of mood and reactivity to psychological stress. This study explores, in a sample of first episode psychosis (FEP) patients, whether more severe depressive symptoms were found in those who: (1) experienced a major stressful event in the 6 months preceding illness onset; and (2) were homozygous for the COMT Val158 allele or carrying the S allele...
Topics
- Humans
- Depression
- Life Change Events
- Psychotic Disorders
- Stress, Psychological
- Genotype
- Catechol O-Methyltransferase